DES (diethylstilbestrol) is one of many chemical exposures that can disrupt reproductive functioning in offspring. Scientists are identifying a wide range of pesticides and industrial chemicals that have a toxic effect on wildlife and humans. Exposed birds, fish, amphibians, reptiles, and mammals are giving birth to offspring who are unable to reproduce. The reproductive injuries parallel those seen in DES-exposed people. Thus, DES is one of many estrogenic exposures to our bodies and environment. And DES exposure is the model for a new inquiry into toxicology and endocrine-disruption.